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(from Green, 1984, p. 662 nd (al) 77. Immunosuppressive Drugs that May Cause Ocular Complications Steroids Prolonged use of glucocorticoids is a significant risk factor for the development of posterior sub- Drug or condition Possible complications Steroids Tacrolimus Cyclosporine Cortical blindness Optic neuropathy Microvascular retinopathy Optic nerve head oedema Cortical blindness Posterior subcapsular cataract Central serous chorioretinopathy Increased intraocular pressure Infectious complications Cytomegalovirus retinitis Herpes zoster retinitis Candida endophthalmitis Aspergillus retinitis Ocular surface complications Herpes simplex keratitis Pseudomembranous Diabetes Sterile and infectious corneal ulceration Keratoconjunctivitis sicca Bacterial and viral conjunctivitis conjunctivitis Diabetic retinopathy Cataract Neovascular glaucoma Neuroophthalmic disorders Alfadolone 149 Structural Formula: Raw Materials Acetic acid Potassium hydroxide Potassium acetate Hydrogen Lead tetraacetate Manufacturing Process 3β-Acetoxy-5α-pregn-16-ene-11,20-dione 4-Toluenesulfonyl chloride Palladium on carbon Boron trifluoride etherate Sodium bicarbonate A solution of 3β-acetoxy-5α-pregn-16-ene-11,20-dione (Chamberlin et al.

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